Application
Applied for culture of mammal and animal cells through batch feeding or continuous perfusion
The large-scale culture technology of animal cells (hybridoma cells, CHO cells, insect cels, etc.) and its bioreactor engineeringcan be widely used in research, development and industrial production of antibodies, recombinant protein drugs, viral vaccinesand other biotechnological products.
The large-scale culture technology of animal cells and its bioreactor system consisting ofsuch core technolgies as serum-free suspension culture technology, culture process and bioreactor design amplification andenhancement technology, large-scale high-density feeding and continuous perfusion culture technology, computer real-timemonitoring and control technology of culture process, large-scale and high-efficiency production technology of virus products,etc. have been established.
Product Description
Bioreactor with single borosilicate glass vessel and stainless steel dish bottom, with the head plate of SS316L at bottom stainless steel jacket. It should have the temperature control via circulation of hot/cold water in the jacket through an inbuilt thermo circulator unit (working temperature range 8ºC-80ºC above coolant temperature). The system be complete to measure and control pH, DO, stirrer speed (25-500rpm), gas, foam and temperature.
Control system: 10in touch screen , Siemens PLC control system with control parameters (stirring, pH, DO, temperature, feeding, gas etc.), data analysis, data logging, data output and printing, overrun alarm, language switching and other functions
Technical parameters
| Total volume | 1L~40L |
| Working volume | 50%~70% |
| Stirring system | Mechanical seal system, shaft, 2 height adjustable six – blade stirrer, removable baffle cage |
| Sterilization | Off-site sterilization(Autoclave) |
| Gas control | Provision for mixing at least four gases (Air, Oxygen, Nitrogen and CO2) Manual control by rotor meter (standard) Auto control by mass flow meter( optional) |
| Feeding | 4 fixed peristaltic pump( standard) Variable speed peristaltic pump(optional) |
| Basic sensor | Stanaded with pH, DO, Temperature, Foam Optional: Liquid Level sensor, OD sensor, Turbidity sensor, ORP sensor, Weight system, Live cell sensor etc. |
