Tetanus spores widely exist in the natural environment, and humans generally have no natural immunity to tetanus. Therefore, artificial immunization is needed to make the body develop immunity to tetanus toxin. There are two methods: active immunity and passive immunity. Vaccination against tetanus is an active immunization.
Mechanism:
The main component of the tetanus vaccine is tetanus toxoid (TT), which is made from attenuated tetanus exotoxin. Active immunity against tetanus is to inoculate the human body with tetanus toxoid, causing the body to produce antibodies against the tetanus toxin, thus acquiring immunity.
Vaccine classification:
Currently, the vaccines used to prevent tetanus in my country include the following five types:
- Adsorbed acellular diphtheria-tetanus pertussis combined vaccine (DTaP): Made from acellular pertussis vaccine stock solution (co-purification process), diphtheria toxoid stock solution and tetanus toxoid stock solution with aluminum hydroxide adjuvant. Used to prevent whooping cough, diphtheria, and tetanus.
- Acellular DTP-Hib conjugate vaccine (DTaP-Hib): The main components are acellular DTP-Hib conjugate vaccine (co-purification process) and Haemophilus influenzae type b conjugate vaccine. For the prevention of whooping cough, diphtheria, tetanus and invasive diseases caused by Haemophilus influenzae type b.
- Adsorbed acellular DPT vaccine inactivated poliomyelitis and Haemophilus influenzae type b (conjugated) combined vaccine (DTaP-IPV//Hib): composed of adsorbed acellular DTP inactivated poliomyelitis combined vaccine, containing It consists of diphtheria toxoid, tetanus toxoid, two purified pertussis antigens (PT and FHA) adsorbed on aluminum hydroxide, and three types of poliovirus and Haemophilus influenzae type b conjugate vaccines. For the prevention of whooping cough, diphtheria, tetanus, poliomyelitis and invasive infections caused by Haemophilus influenzae type b.
- Adsorbed diphtheria-tetanus combined vaccine (DT): Made from diphtheria toxoid stock solution and tetanus toxoid stock solution with aluminum hydroxide adjuvant added. It is used for booster immunization against diphtheria and tetanus in children who have been fully immunized with adsorbed pertussis, diphtheria and tetanus combined vaccine.
- The adsorbed tetanus vaccine is made by using Clostridium tetanus, culturing the toxin in a suitable culture medium, detoxifying and refining it with formaldehyde, and adding aluminum hydroxide adjuvant. Used to prevent tetanus.
Among them, DTaP and DT are immunization program vaccines, and DTaP-Hib, DTaP-IPV//Hib and adsorbed tetanus vaccine are non-immunization program vaccines.
Vaccine technology:
- Strain activation (the production strain used in China is L58 strain)
- To cultivate toxin production, deep culture in culture tanks is used. Adding organelles to the culture medium will reduce the level of toxin production in both production and epigenetic parameters. In addition, ventilation is required. method to remove hydrogen sulfide and carbon dioxide)
- Formaldehyde heating detoxification (the method currently used is 0.36% formaldehyde, pH neutral, 37C detoxification for 30 days
- Concentration and purification (concentration by ultrafiltration, sulfuric acid precipitation)
- Sterilization filtration (remove bacteria through 0.22um microporous membrane filtration)
- Adsorption and purification of tetanus toxin (adsorption with gaseous alumina)
Bailun Tetanus Vaccine Technology:
Perfect sealing design, automatic CIP and SIP provide safety guarantee for the production of highly pathogenic toxins: the unique exhaust gas treatment device effectively removes harmful gases and protects the environment while ensuring biological safety.
Tetanus culture system:
The reactor height-to-diameter ratio is 2:1, suitable for the cultivation of Clostridium tetanus
Surface ventilation design, AIR automatic flow adjustment.
About BaiLun Biotechnology Co., Ltd
BaiLun Bio is a supplier and technical service provider of whole-set bioreactors (fermenter) and control systems. Our products include bioreactors (fermenter), animal cell bioreactors, bioreactor shakers, biological shakers, bottle rockers, control systems for bioreactors, etc. We can produce bioreactors with different volumes of 0.1L-1000KL and make our contributions for China′s bioreactor business to thrive throughout the world.
BaiLun has a contingent of engineers who have rich experience in fermenting processes, biochemical equipment and chemical technology. In addition, we also invite many nationally famous experts and scholars to act as our technical consultants, so as to ensure that our products have strong and steady technological foundations. The innovation of products and the technology leadership are the core parts of our products. Ensuring customer satisfaction is our permanent pursuit. Taking customer benefit as our own responsibility is the core value of Bailun Company.
Our company offers variety of products which can meet your multifarious demands. We adhere to the management principles of “quality first, customer first and credit-based” since the establishment of the company and always do our best to satisfy potential needs of our customers. Our company is sincerely willing to cooperate with enterprises from all over the world in order to realize a win-win situation since the trend of economic globalization has developed with an irresistible force.
BaiLun spirit: Customer foremost, seeking quality, fairness and honesty, continuous improvement and innovation.
Contact Us:
Add:6848# Liuxiang Rd., Jiading, Shanghai, China
Contact Person: Maddie
Email:sales@fermentertech.com
Phone:+86-134-7276-8163 (WhatsApp)
Website: http://fermenterchina.com/
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